Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 72 (12), 1100-16

Boswellic Acids in Chronic Inflammatory Diseases

Affiliations
Review

Boswellic Acids in Chronic Inflammatory Diseases

H P T Ammon. Planta Med.

Abstract

Oleogum resins from BOSWELLIA species are used in traditional medicine in India and African countries for the treatment of a variety of diseases. Animal experiments showed anti-inflammatory activity of the extract. The mechanism of this action is due to some boswellic acids. It is different from that of NSAID and is related to components of the immune system. The most evident action is the inhibition of 5-lipoxygenase. However, other factors such as cytokines (interleukins and TNF-alpha) and the complement system are also candidates. Moreover, leukocyte elastase and oxygen radicals are targets. Clinical studies, so far with pilot character, suggest efficacy in some autoimmune diseases including rheumatoid arthritis, Crohn's disease, ulcerative colitis and bronchial asthma. Side effects are not severe when compared to modern drugs used for the treatment of these diseases.

Similar articles

See all similar articles

Cited by 40 PubMed Central articles

See all "Cited by" articles

MeSH terms

LinkOut - more resources

Feedback