Assessment of anti-inflammatory activity of Poria cocos in sodium lauryl sulphate-induced irritant contact dermatitis

Skin Res Technol. 2006 Nov;12(4):223-7. doi: 10.1111/j.0909-752X.2006.00168.x.

Abstract

Objective: In the present study, we evaluated the anti-inflammatory activity of Poria cocos (PoCo) on experimentally induced irritant contact dermatitis (ICD) in a repeated sodium lauryl sulphate (SLS) irritation model.

Methods: The anti-irritative effect of PoCo was evaluated with a visual score and quantified by non-invasive bioengineering methods, namely chromametry and transepidermal water loss. Three concentrations of PoCo in base cream DAC (amphiphilic emollient; German pharmacopoeia) were tested in a 4-day repetitive irritation test using SLS.

Results: A statistically significant anti-inflammatory activity was observed for PoCo by all three methods when applied in parallel to the induction period of ICD. Application of PoCo after induction of ICD once a day for 5 days, starting just at the end of 4 days, was without any effect.

Conclusion: An anti-inflammatory efficacy of PoCo on the elicitation phase of the ICD induced by repeated SLS test could be observed and quantified by three independent, non-invasive biophysical assessment parameters. This effect can be explained by its influence on pro-inflammatory enzymes, namely phospholipase A2.

Publication types

  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / isolation & purification*
  • Anti-Inflammatory Agents / therapeutic use*
  • Dermatitis, Irritant / drug therapy*
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Male
  • Polyporales / chemistry*
  • Single-Blind Method
  • Skin / drug effects
  • Sodium Dodecyl Sulfate*
  • Surface-Active Agents*
  • Treatment Outcome

Substances

  • Anti-Inflammatory Agents
  • Surface-Active Agents
  • Sodium Dodecyl Sulfate