Serum granulocyte colony-stimulating factor levels in chronic neutropenia of infancy

Pediatr Hematol Oncol. 1990;7(4):377-81. doi: 10.3109/08880019009033415.


Eight infants with chronic neutropenia ranging in age from 1 to 13 months were studied for serum granulocyte colony-stimulating factor (G-CSF) levels. Serum G-CSF levels were elevated, especially when peripheral blood absolute neutrophil counts (ANC) were under 500/microliter in seven patients with autoimmune neutropenia. On the other hand, in a patient with congenital agranulocytosis (Kostmann type), G-CSF levels were below the sensitivity of the assay (less than 50 pg/ml) despite severe neutropenia (less than 100/microliter).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autoantibodies / analysis
  • Chronic Disease
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Granulocyte Colony-Stimulating Factor / blood*
  • Humans
  • Infant
  • Leukocyte Count
  • Male
  • Neutropenia / blood*
  • Neutrophils / immunology


  • Autoantibodies
  • Granulocyte Colony-Stimulating Factor