Natural inhibitors targeting osteoclast-mediated bone resorption

Bioorg Med Chem Lett. 2006 Dec 15;16(24):6178-80. doi: 10.1016/j.bmcl.2006.09.042. Epub 2006 Oct 5.

Abstract

Human cathepsin K, matrix metalloproteinase 9, and alpha(V)beta(3) integrin are the key regulators in osteoclast-mediated bone resorption. In this paper, we found natural inhibitors 1-10 for them by enzyme inhibition assays. Inhibitors 1-7, 8-9, and 10 are novel inhibitors of human cathepsin K, matrix metalloproteinase 9, and alpha(V)beta(3), respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bone Resorption / prevention & control*
  • Cathepsin K
  • Cathepsins / antagonists & inhibitors
  • Drug Design
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Humans
  • Integrin alphaVbeta3 / antagonists & inhibitors*
  • Matrix Metalloproteinase Inhibitors
  • Osteoclasts / drug effects
  • Osteoclasts / physiology*
  • Protease Inhibitors / chemistry
  • Protease Inhibitors / pharmacology

Substances

  • Enzyme Inhibitors
  • Integrin alphaVbeta3
  • Matrix Metalloproteinase Inhibitors
  • Protease Inhibitors
  • Cathepsins
  • CTSK protein, human
  • Cathepsin K