The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America

Clin Infect Dis. 2006 Nov 1;43(9):1089-134. doi: 10.1086/508667. Epub 2006 Oct 2.


Evidence-based guidelines for the management of patients with Lyme disease, human granulocytic anaplasmosis (formerly known as human granulocytic ehrlichiosis), and babesiosis were prepared by an expert panel of the Infectious Diseases Society of America. These updated guidelines replace the previous treatment guidelines published in 2000 (Clin Infect Dis 2000; 31[Suppl 1]:1-14). The guidelines are intended for use by health care providers who care for patients who either have these infections or may be at risk for them. For each of these Ixodes tickborne infections, information is provided about prevention, epidemiology, clinical manifestations, diagnosis, and treatment. Tables list the doses and durations of antimicrobial therapy recommended for treatment and prevention of Lyme disease and provide a partial list of therapies to be avoided. A definition of post-Lyme disease syndrome is proposed.

Publication types

  • Practice Guideline

MeSH terms

  • Anaplasmosis / drug therapy
  • Anaplasmosis / physiopathology
  • Anaplasmosis / prevention & control*
  • Animals
  • Babesiosis / drug therapy
  • Babesiosis / physiopathology
  • Babesiosis / prevention & control*
  • Ehrlichiosis / prevention & control
  • Health Personnel
  • Humans
  • Lyme Disease / diagnosis
  • Lyme Disease / drug therapy
  • Lyme Disease / physiopathology
  • Lyme Disease / prevention & control*
  • Syndrome
  • Tick-Borne Diseases / drug therapy
  • Tick-Borne Diseases / physiopathology
  • Tick-Borne Diseases / prevention & control*