Long-term effect of cromolyn sodium on nonspecific bronchial hyperresponsiveness: a review

Ann Allergy. 1991 Jan;66(1):53-63.


Long-term treatment with cromolyn sodium will reduce airway hyperresponsiveness in patients with bronchial asthma. Short-term use of cromolyn sodium (less than 6 weeks) is effective in preventing seasonal increases in allergen-induced hyperresponsiveness. Cromolyn sodium therapy for greater than 12 weeks appears to be beneficial in reducing baseline hyperresponsiveness. The effect of cromolyn sodium on bronchial hyperresponsiveness may result from its ability to stabilize mast cells. Other contributory properties of cromolyn sodium are reviewed.

Publication types

  • Review

MeSH terms

  • Animals
  • Asthma / drug therapy*
  • Asthma / physiopathology
  • Bronchi / drug effects*
  • Bronchi / physiopathology
  • Chemotaxis, Leukocyte / drug effects
  • Cromolyn Sodium / pharmacology
  • Cromolyn Sodium / therapeutic use*
  • Eosinophils / drug effects
  • Histamine Release / drug effects
  • Humans


  • Cromolyn Sodium