Severe vocal cord dysfunction resistant to all current therapeutic interventions

Respir Med. 2007 Apr;101(4):857-8. doi: 10.1016/j.rmed.2006.08.009. Epub 2006 Oct 6.


Vocal cord dysfunction (VCD) is characterised by paradoxical vocal cord adduction during inspiration or throughout the respiratory cycle, it results in wheeze, stridor, cough and dyspnoea. Although asthma and VCD can coexist, patients with VCD are frequently misdiagnosed with refractory asthma. It can severely restrict an individual's level of activity and effective therapeutic control can be difficult to achieve. We report the case of a patient who was treated with all available therapeutic interventions, including intralaryngeal botulinum toxin injection, but failure resulted in a permanent trachesotomy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Dyskinesia Agents / administration & dosage
  • Asthma / complications
  • Asthma / drug therapy
  • Botulinum Toxins / administration & dosage
  • Humans
  • Injections
  • Laryngeal Diseases / complications
  • Laryngeal Diseases / physiopathology
  • Laryngeal Diseases / therapy*
  • Male
  • Respiratory Therapy / methods
  • Speech Therapy / methods
  • Tracheostomy / methods
  • Treatment Failure
  • Vocal Cords / physiopathology*


  • Anti-Dyskinesia Agents
  • Botulinum Toxins