Mumps resurgence in the United States

J Allergy Clin Immunol. 2006 Oct;118(4):938-41. doi: 10.1016/j.jaci.2006.07.033. Epub 2006 Aug 28.


The recent mumps epidemic in the central United States has generated a large amount of public concern. A total of 2597 mumps cases have been reported in the United States in 11 states since January 1, 2006, representing a marked resurgence of mumps in a single year. The majority of these recent cases have occurred in college students age 18 to 25 years. Most were vaccinated with 2 doses of measles, mumps, and rubella-containing vaccines. Such outbreaks provide an opportunity for clinicians to review the clinical presentation, diagnosis, and morbidity of vaccine-preventable infections and also to review immunologic mechanisms and practice guidelines that might contribute to poor vaccine responses. A review of mumps is provided with discussion of potential mechanisms for vaccine failure.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Adult
  • Disease Outbreaks*
  • Humans
  • Mumps / epidemiology*
  • Mumps Vaccine*
  • United States


  • Mumps Vaccine