A quantitative trait locus for body fat on chromosome 1q43 in French Canadians: linkage and association studies

Obesity (Silver Spring). 2006 Sep;14(9):1605-15. doi: 10.1038/oby.2006.185.


Objective: To explore a quantitative trait locus (QTL) on human chromosome 1q affecting BMI, adiposity, and fat-free mass phenotypes in the Quebec Family Study cohort.

Research methods and procedures: Non-parametric sibpair and variance component linkage analyses and family-based association studies were performed with a dense set of chromosome 1q43 microsatellites and single-nucleotide polymorphism markers in 885 adult individuals.

Results: Linkage was observed between marker D1S184 and BMI (p = 0.0004) and with body fat mass or percentage body fat (p < or = 0.0003), but no linkage was detected with fat-free mass. Furthermore, significant linkages (p < 0.0001) were achieved with subsamples of sibpairs at both ends of phenotype distributions. Association studies with quantitative transmission disequilibrium tests refined the linkage to a region overlapping the regulator of G-protein signaling 7 (RGS7) gene and extending to immediate upstream gene loci.

Discussion: The present study indicates that the QTL on chromosome 1q43 specifically affects total adiposity and provides a genetic mapping framework for the dissection of this adiposity locus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / metabolism*
  • Adolescent
  • Adult
  • Aged
  • Body Composition / genetics*
  • Body Mass Index
  • Chromosomes, Human, Pair 1 / genetics*
  • Cohort Studies
  • Female
  • Gene Frequency
  • Genetic Linkage*
  • Genotype
  • Health Surveys
  • Humans
  • Male
  • Microsatellite Repeats
  • Middle Aged
  • Obesity / genetics*
  • Polymorphism, Single Nucleotide
  • Quantitative Trait Loci*
  • Quebec