Effect of a Viscous Fiber Bar on Postprandial Glycemia in Subjects With Type 2 Diabetes

J Am Coll Nutr. 2006 Oct;25(5):409-14. doi: 10.1080/07315724.2006.10719553.

Abstract

Objective: To compare the effect of an experimental viscous fiber (VF) crispy bar on the postprandial glucose, insulin, and C-peptide response in adult subjects with type 2 diabetes to two commercially available control crispy bars.

Design: The study was a randomized, double-blinded, three period, crossover study.

Setting: The study was conducted at two sites: Park Nicollet Institute, International Diabetes Center, Minneapolis, MN, and Radiant Research, Inc., Minneapolis, MN.

Subjects: A total of 60 adults with type 2 diabetes taking oral antihyperglycemic medication participated in the study.

Intervention: After an overnight fast, subjects consumed a test meal containing an equicaloric amount (300 kcal) of an experimental VF crispy bar or one of two commercially available crispy bars at each of three test visits, followed by a four hour meal tolerance test. Subjects also completed gastrointestinal (GI) response records for the 24 hours following each test visit.

Results: The VF crispy bars produced significantly lower glucose (p < 0.0001), insulin (p < 0.0001), and C-peptide (p < 0.0001) responses (as measured by positive area under the curve) in subjects with type 2 diabetes, as compared with the two commercially available bars. Intensity (p < 0.05) and frequency (p < 0.05) of flatulence were significantly higher with the VF bar as compared with the 2 commercial bars. While the VF bar produced significant subjective GI tolerance scoring values, the mean value was below 3 on a scale of 0 (no effect) to 10 (most severe effect) for all tested materials.

Conclusions: The incorporation of VF into a crispy bar provided a means to improve blood glucose levels by reducing postprandial glucose, insulin, and C-peptide responses in subjects with type 2 diabetes. Though associated with some GI symptoms, VF may have application in improving the postprandial glycemic response in people with diabetes attempting intensive glucose control.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Area Under Curve
  • Blood Glucose / metabolism*
  • C-Peptide / blood*
  • Cross-Over Studies
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / diet therapy*
  • Dietary Fiber* / administration & dosage
  • Dietary Fiber* / adverse effects
  • Dietary Fiber* / metabolism
  • Double-Blind Method
  • Female
  • Flatulence / epidemiology*
  • Humans
  • Insulin / metabolism*
  • Intestinal Absorption
  • Male
  • Middle Aged
  • Postprandial Period
  • Viscosity

Substances

  • Blood Glucose
  • C-Peptide
  • Dietary Fiber
  • Insulin