Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI

Biosci Biotechnol Biochem. 2006 Oct;70(10):2371-80. doi: 10.1271/bbb.50698. Epub 2006 Oct 7.


The active ingredients of 'golden root' of Scutellaria baicalensis GEORGI (Huang-Qin), a valuable traditional Chinese medicine, are polyhydroxyflavonoids, namely baicalein, oroxylin A and wogonin. With the objective of overcoming their poor solubility and to investigate their structure and activity relationships, baicaleinyl 7-O-sulfate was prepared, and extensive comparative antioxidative and anti-inflammatory tests were conducted. All the polyhydroxyflavonoids exhibited significant antioxidative and free-radical scavenging activities. In respect of their nitric oxide (NO) inhibition, wogonin was superior to all the other flavonoids, while oroxylin A was most potent in the inhibition of lipid peroxidation. Wogonin proved to be the most potent (82.9% inhibition, p<0.05) in its anti-inflammatory activity against carrageenan-induced rat hind paw edema. There was a correlation between the in-vivo anti-inflammatory activity and the in-vitro antioxidative activities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Antioxidants / pharmacology*
  • Drugs, Chinese Herbal
  • Edema / drug therapy
  • Flavanones / chemistry
  • Flavanones / pharmacology
  • Flavanones / therapeutic use
  • Flavonoids / chemistry
  • Flavonoids / pharmacology*
  • Flavonoids / therapeutic use
  • Free Radical Scavengers
  • Lipid Peroxidation / drug effects
  • Nitric Oxide / antagonists & inhibitors
  • Phytotherapy
  • Rats
  • Scutellaria baicalensis / chemistry*
  • Solubility
  • Structure-Activity Relationship


  • Anti-Inflammatory Agents
  • Antioxidants
  • Drugs, Chinese Herbal
  • Flavanones
  • Flavonoids
  • Free Radical Scavengers
  • Nitric Oxide
  • baicalein
  • 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one
  • wogonin