The molecular physiology of human limb immobilization and rehabilitation

Exerc Sport Sci Rev. 2006 Oct;34(4):159-63. doi: 10.1249/01.jes.0000240017.99877.8a.


This short review will identify some of the molecular signaling events that regulate atrophy during immobilization in human skeletal muscle and how prescribed exercise rehabilitation may influence these signaling events. The potential for nutritional intervention to positively modulate molecular signaling and thereby offset muscle wasting and/or accelerate rehabilitation in humans will also be considered.

Publication types

  • Review

MeSH terms

  • Animals
  • Diet
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Humans
  • Immobilization*
  • Muscle, Skeletal / metabolism*
  • Muscular Atrophy / genetics*
  • Muscular Atrophy / metabolism
  • Muscular Atrophy / rehabilitation*