The role of SUMO in chromosome segregation

Chromosoma. 2007 Feb;116(1):15-20. doi: 10.1007/s00412-006-0079-z. Epub 2006 Oct 10.

Abstract

Chromosome segregation is an essential feature of the eukaryotic cell cycle. Efficient chromosome segregation requires the co-ordination of several cellular processes; some of which involve gross rearrangements of the overall structure of the genetic material. Recent advances in the analysis of the role of SUMO (small ubiquitin-like modifier) and in the identification of SUMO-modified targets indicate that sumoylation is likely to have several key roles in regulating chromosome segregation This mini-review summarises the recently published data concerning the role of SUMO in the processes required for efficient chromosome segregation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism
  • Chromosome Painting
  • Chromosome Segregation / physiology*
  • Humans
  • Multiprotein Complexes
  • Mutation
  • SUMO-1 Protein / physiology*
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / metabolism
  • Spindle Apparatus

Substances

  • Cell Cycle Proteins
  • Multiprotein Complexes
  • SMC5 protein, S cerevisiae
  • SMC6 protein, S cerevisiae
  • SUMO-1 Protein
  • Saccharomyces cerevisiae Proteins