Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer study (AAHPC)

Prostate. 2007 Jan 1;67(1):22-31. doi: 10.1002/pros.20456.

Abstract

Background: The African American Hereditary Prostate Cancer (AAHPC) Study was designed to recruit families with early-onset disease fulfilling criteria of >or=4 affected.

Methods: We present a approximately 10 cM genome-wide linkage (GWL) analysis on 77 families including 254 affected and 274 unaffected genotyped.

Results: Linkage analysis revealed three chromosomal regions with GENEHUNTER multipoint HLOD scores >or=1.3 for all 77 families at 11q22, 17p11, and Xq21. One family yielded genome-wide significant evidence of linkage (LOD = 3.5) to the 17p11 region with seven other families >or=2.3 in this region. Twenty-nine families with no-male-to-male (MM) transmission gave a peak HLOD of 1.62 (alpha = 0.33) at the Xq21 locus. Two novel peaks >or=0.91 for the 16 families with '>6 affected' occurred at 2p21 and 22q12.

Conclusions: These chromosomal regions in the genome warrant further follow-up based on the hypothesis of multiple susceptibility genes with modest effects, or several major genes segregating in small subsets of families.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

MeSH terms

  • African Americans / genetics*
  • Aged
  • Genetic Linkage / genetics*
  • Genetic Markers / genetics
  • Genome, Human
  • Humans
  • Lod Score
  • Male
  • Middle Aged
  • Pedigree
  • Prostatic Neoplasms / genetics*
  • United States

Substances

  • Genetic Markers