Adipocyte fatty-acid binding protein is closely associated to the porcine FAT1 locus on chromosome 4

J Anim Sci. 2006 Nov;84(11):2907-13. doi: 10.2527/jas.2005-663.


We identified 22 polymorphisms in the adipocyte fatty-acid binding protein (FABP4) gene, a strong positional candidate gene for the FAT1 locus in porcine chromosome 4. The most informative polymorphism, an insertion/deletion in intron 1, together with a single nucleotide polymorphism in intron 3, was genotyped in a cross between Iberian and Landrace pigs. After performing QTL, single marker, and haplotype analyses, we showed that there were at least 2 quantitative trait genes in the FAT1 region and that the FABP4 polymorphism was tightly associated to fatness. A comparison of allelic frequencies in a panel of pig breeds suggested that the Del2634C polymorphism was under indirect selection. We also showed that FABP4 is tightly associated to fatness but not growth. Furthermore, a haplotype analysis suggests that there is genetic heterogeneity at the FAT1 locus within the Landrace breed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromosome Mapping
  • Fatty Acid-Binding Proteins / genetics*
  • Female
  • Male
  • Polymorphism, Genetic
  • Quantitative Trait Loci
  • Swine / genetics*


  • Fatty Acid-Binding Proteins