In search for new antipsoriatic agents: NAD topical composition

Skin Pharmacol Physiol. 2007;20(1):37-42. doi: 10.1159/000096170. Epub 2006 Oct 11.

Abstract

The aim of the study was to examine the effectiveness of the oxidized form of nicotinamide adenine dinucleotide (NAD(+)), adenosine precursor, in 37 patients suffering from psoriasis. As NAD(+) is known to be relatively unstable, the second goal was to establish the proper conditions for the satisfactory stability of topical NAD(+) composition. In each patient, two matching plaques were selected for the study. Topical treatment with 1 or 0.3% NAD(+) in Vaseline ointment administered twice daily was compared with overnight therapy with 0.1% anthralin applied for 12 h and placebo. The enzymatic method was applied to determine the stability of NAD(+) in Vaseline ointment. After a 4-week application, the reduction in erythema, infiltration and desquamation caused by 1 or 0.3% topical NAD(+) composition was similar to the reduction caused by 0.1% anthralin. It was demonstrated that NAD(+) underwent a considerable decomposition at room temperature, while it was sufficiently stable at 5 degrees C; thus, for a longer use the agent should be stored at fridge temperature. NAD(+) therapy combines good efficacy, cosmetic acceptability and convenient twice-daily application.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Adult
  • Anthralin / therapeutic use
  • Chemistry, Pharmaceutical
  • Dermatologic Agents / therapeutic use*
  • Drug Stability
  • Female
  • Humans
  • Male
  • Middle Aged
  • NAD / administration & dosage
  • NAD / therapeutic use*
  • Ointments
  • Psoriasis / drug therapy*

Substances

  • Dermatologic Agents
  • Ointments
  • NAD
  • Anthralin