Anti-inflammatory and skin-hydrating properties of a dietary supplement and topical formulations containing oligomeric proanthocyanidins

Skin Pharmacol Physiol. 2007;20(1):43-9. doi: 10.1159/000096171. Epub 2006 Oct 11.


Background: Anti-inflammatory and skin hydration properties of a dietary supplement and 2 topical formulations (Anthogenol) with oligomeric proanthocyanidins were investigated.

Methods: Forty-two subjects were randomized into 2 groups: one taking the dietary supplement (100 mg/day) and the other without supplement. After 4 weeks, erythema was induced using UV radiation followed by treatment with topical cream or lotion. Erythema was measured for up to 72 h after irradiation. Skin hydration after 1 and 2 weeks of application of the cream and lotion was also measured in separate test fields.

Results: Both topical formulations led to a significant suppression of erythema formation and the dietary supplement led to an additional slightly stronger suppression. Thus 72 h after UV exposure and compared to the control fields of patients that had not taken a dietary supplement, erythema was slightly (13.2%) lower in the subjects that had taken a dietary supplement. The cream resulted in a maximal reduction of erythema of 45.9% (p = 0.0015), while the lotion resulted in a maximal reduction of 53.1% (p = 0.0002). Both topical formulations also increased skin hydration (by nearly 20%; p < 0.002 for all combinations of dietary supplementation and topical treatment) and the hydration was higher in the group taking the dietary supplement.

Conclusion: The regular use of Anthogenol products may help to protect from free-radical-mediated skin inflammation and to increase skin hydration.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Adult
  • Anti-Inflammatory Agents / therapeutic use*
  • Chemistry, Pharmaceutical
  • Dietary Supplements*
  • Erythema / etiology
  • Erythema / prevention & control*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Proanthocyanidins / therapeutic use*
  • Ultraviolet Rays / adverse effects*


  • Anti-Inflammatory Agents
  • Proanthocyanidins