Management of clinically diagnosed subacute rhinosinusitis in children under the age of two years: a randomized, controlled study

J Laryngol Otol. 2006 Oct;120(10):845-8. doi: 10.1017/S0022215106000776.

Abstract

Background: In children, a diagnosis of rhinosinusitis is usually made on clinical grounds. Subacute rhinosinusitis (SRS) may be the cause of persistent cough, low-grade fever, snoring, ear problems and difficult feeding in children under the age of two years.

Objective: To compare the efficacy of culture-based antibiotics and empiric amoxicillin-clavulanate (40 mg/kg/day) in treating SRS in children under the age of two years.

Study design: Randomized, controlled study.

Population: Sixty children with persistent nasal discharge and nasal obstruction (and other related symptoms) for 30-90 days.

Methods: Group one (n = 30) received culture-based antibiotics and group two (n = 30) were treated empirically with 40 mg/kg/day of amoxicillin-clavulanate. Treatment was continued for two weeks.

Results: At the end of the three-week follow-up period, statistically significant greater improvements in nasal obstruction (p = 0.037) and nasal discharge (p = 0.003) were seen in group one compared with group two.

Conclusion: culture-based antibiotics were more efficacious than empiric amoxicillin-clavulanate (40 mg/kg/day) in treating SRS in children under the age of two years.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Amoxicillin-Potassium Clavulanate Combination / therapeutic use*
  • Anti-Bacterial Agents / therapeutic use*
  • Child, Preschool
  • Drug Therapy, Combination
  • Female
  • Humans
  • Infant
  • Male
  • Sinusitis / diagnosis
  • Sinusitis / drug therapy*
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Amoxicillin-Potassium Clavulanate Combination