Endovascular repair of thoracic aortic aneurysms offers a less invasive alternative to conventional surgery, similar to its counterpart in the abdominal aorta. Although its long-term durability and outcome remain relatively unknown, published midterm results from clinical trials suggest comparable rates of aneurysm-related mortality and significant reductions in early morbidity compared with open repair. The Zenith TX2 stent graft (Cook Endovascular, Bloomington, IN) is an investigational endovascular device that is designed to treat aneurysms and other degenerative pathologies of the thoracic aorta. At the time of this writing, it is nearing completion of its pivotal trial. Clinical experience with this device is limited to countries outside the United States and to sites participating in the clinical trials. The purpose of this article is to provide a description of the Zenith TX2 device and its application in the repair of thoracic aortic aneurysms and dissections.