Group B streptococcal pilus proteins contribute to adherence to and invasion of brain microvascular endothelial cells

J Bacteriol. 2007 Feb;189(4):1464-7. doi: 10.1128/JB.01153-06. Epub 2006 Oct 13.

Abstract

Surface filamentous structures known as pili have been discovered recently in the gram-positive streptococcal pathogens that cause invasive disease in humans, including group B Streptococcus (GBS). We show that two GBS proteins involved in pilus formation, encoded by pilA and pilB, also facilitate the interaction of this important agent of central nervous system infection with endothelial cells of the human blood-brain barrier.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Bacterial Adhesion / physiology*
  • Bacterial Proteins / biosynthesis*
  • Bacterial Proteins / genetics
  • Brain / blood supply
  • Cells, Cultured
  • Endothelial Cells / microbiology*
  • Fimbriae Proteins / biosynthesis*
  • Fimbriae Proteins / genetics
  • Fimbriae, Bacterial / metabolism*
  • Gene Expression Regulation, Bacterial
  • Humans
  • Oxidoreductases / biosynthesis*
  • Oxidoreductases / genetics
  • Streptococcus agalactiae / metabolism*

Substances

  • Bacterial Proteins
  • Fimbriae Proteins
  • Oxidoreductases
  • pilB protein, Bacteria