Identification of the FtsK sequence-recognition domain

Nat Struct Mol Biol. 2006 Nov;13(11):1023-5. doi: 10.1038/nsmb1157. Epub 2006 Oct 15.


FtsK is a prokaryotic multidomain DNA translocase that coordinates chromosome segregation and cell division. FtsK is membrane anchored at the division septum and, guided by highly skewed DNA sequences, translocates the chromosome to bring the terminus of replication to the septum. Here, we use in vitro single-molecule and ensemble methods to unveil a mechanism of action in which the translocation and sequence-recognition activities are performed by different domains in FtsK.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Chromosomes, Bacterial / metabolism
  • DNA, Bacterial / metabolism
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / metabolism
  • Escherichia coli / chemistry*
  • Escherichia coli / enzymology
  • Escherichia coli / metabolism
  • Escherichia coli Proteins / chemistry*
  • Escherichia coli Proteins / metabolism
  • Membrane Proteins / chemistry*
  • Membrane Proteins / metabolism
  • Protein Structure, Tertiary


  • DNA, Bacterial
  • DNA-Binding Proteins
  • Escherichia coli Proteins
  • FtsK protein, E coli
  • Membrane Proteins