Vascular tumor targeting

Q J Nucl Med Mol Imaging. 2006 Dec;50(4):296-309.

Abstract

The growth of solid tumors is dependent on their capacity to acquire blood supply. Therefore, much effort has been directed towards the development of anti-angiogenic agents which inhibit the process of neovascularization. More recently, it has become apparent that the targeted destruction of the established tumor vasculature represents a complementary avenue for growing therapeutic opportunities. This review provides evidence that vascular tumor targeting is an effective anti-tumor strategy in animal models. It further describes strategies for the identification of putative tumor vascular targets and discusses future prospects for vascular targeting applications in the clinical setting.

Publication types

  • Review

MeSH terms

  • Drug Delivery Systems / methods*
  • Humans
  • Neoplasms / blood supply*
  • Neoplasms / radiotherapy*
  • Neovascularization, Pathologic / radiotherapy*
  • Radioisotopes / therapeutic use*
  • Radiopharmaceuticals / therapeutic use*

Substances

  • Radioisotopes
  • Radiopharmaceuticals