Spinal-injured neuropathic bladder antisepsis (SINBA) trial

Spinal Cord. 2007 Aug;45(8):542-50. doi: 10.1038/sj.sc.3101974. Epub 2006 Oct 17.


Objective: To determine whether Methenamine Hippurate (MH) or cranberry tablets prevent urinary tract infections (UTI) in people with neuropathic bladder following spinal cord injury (SCI).

Study design: Double-blind factorial-design randomized controlled trial (RCT) with 2 year recruitment period from November 2000 and 6 month follow-up.

Setting: In total, 543 eligible predominantly community dwelling patients were invited to participate in the study, of whom 305 (56%) agreed.

Methods: Eligible participants were people with SCI with neurogenic bladder and stable bladder management. All regimens were indistinguishable in appearance and taste. The dose of MH used was 1 g twice-daily. The dose of cranberry used was 800 mg twice-daily. The main outcome measure was the time to occurrence of a symptomatic UTI.

Results: Multivariate analysis revealed that patients randomized to MH did not have a significantly longer UTI-free period compared to placebo (HR 0.96, 95% CI: 0.68-1.35, P=0.75). Patients randomized to cranberry likewise did not have significantly longer UTI-free period compared to placebo (HR 0.93, 95% CI: 0.67-1.31, P=0.70).

Conclusion: There is no benefit in the prevention of UTI from the addition of MH or cranberry tablets to the usual regimen of patients with neuropathic bladder following SCI.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Infective Agents, Urinary / therapeutic use*
  • Double-Blind Method
  • Female
  • Hippurates / therapeutic use*
  • Humans
  • Male
  • Methenamine / analogs & derivatives*
  • Methenamine / therapeutic use
  • Middle Aged
  • Multivariate Analysis
  • Phytotherapy
  • Plant Extracts / therapeutic use*
  • Spinal Cord Injuries / complications*
  • Tablets
  • Treatment Failure
  • Urinary Bladder, Neurogenic / drug therapy*
  • Urinary Bladder, Neurogenic / etiology*
  • Urinary Tract Infections / prevention & control*
  • Vaccinium macrocarpon / chemistry*


  • Anti-Infective Agents, Urinary
  • Hippurates
  • Plant Extracts
  • Tablets
  • Methenamine
  • methenamine hippurate