Intermediate-term and long-term results after treatment by cidofovir and excision in juvenile laryngeal papillomatosis

Ann Otol Rhinol Laryngol. 2006 Sep;115(9):667-72. doi: 10.1177/000348940611500903.


Objectives: We assessed the intermediate-term and long-term efficacy of intralesional injection of cidofovir used with surgical excision in juvenile-onset recurrent respiratory papillomatosis.

Methods: The protocol was revised during the study, from endoscopy at 4-week intervals with intralesional injection of cidofovir at 5 mg/mL, to a 2-week interval and a 7.5-mg/mL dosage. Partial surgical excision of hypertrophic papillomas was performed before the initiation of injection. Further injections at 4-week (or 2-week) intervals were performed until complete remission.

Results: Sixteen patients received a mean 8.9 injections. Complete remission was obtained in 12 patients (75%) after a mean 7.2 endoscopic treatments. Remission was stable at a mean 33.6 months' follow-up. Five of these 12 patients received 5.2 injections and remained disease-free at a mean 39.3 months' follow-up. Seven of the 12 had 1 relapse; they needed complementary treatment to become disease-free, and remained so thereafter over a mean 27.3 months' follow-up. The other 4 of the 16 patients (25%) continued to present active disease.

Conclusions: Active endoscopic treatment until complete remission led to a higher-than-expected complete remission rate on intermediate-term to long-term follow-up, with or without relapse. Transient relapse was associated with a long delay in initiating cidofovir treatment.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Antiviral Agents / therapeutic use*
  • Child
  • Child, Preschool
  • Cidofovir
  • Combined Modality Therapy
  • Cytosine / analogs & derivatives*
  • Cytosine / therapeutic use
  • Female
  • Follow-Up Studies
  • Humans
  • Injections, Intralesional
  • Laryngeal Neoplasms / therapy*
  • Laryngeal Neoplasms / virology
  • Laryngoscopy*
  • Male
  • Organophosphonates / therapeutic use*
  • Papilloma / therapy*
  • Papilloma / virology
  • Papillomavirus Infections / complications
  • Papillomavirus Infections / therapy
  • Prospective Studies
  • Secondary Prevention
  • Severity of Illness Index
  • Treatment Outcome


  • Antiviral Agents
  • Organophosphonates
  • Cytosine
  • Cidofovir