Selection for more of the same product as a force to enhance concerted evolution of duplicated genes

Trends Genet. 2006 Dec;22(12):642-4. doi: 10.1016/j.tig.2006.09.014. Epub 2006 Oct 11.


The duration of concerted evolution after gene duplication is highly variable across genes. To identify the cause of the variation, we analyzed of duplicated genes in yeast that originate from a whole genome duplication event. There appears to be a strong positive correlation between the duration of concerted evolution and the gene expression level. This observation can be explained by selection favoring more of the same product, which could enhance concerted evolution in dosage-sensitive genes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Evolution, Molecular*
  • Fungal Proteins / metabolism
  • Gene Dosage
  • Gene Duplication*
  • Gene Expression Regulation, Fungal*
  • Genes, Fungal*
  • Genetic Variation
  • Genome, Fungal
  • Models, Genetic
  • Phylogeny
  • Ribosomes / metabolism
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae / metabolism
  • Selection, Genetic
  • Temperature


  • Fungal Proteins