Nuclear anarchy: asynchronous mitosis in multinucleated fungal hyphae

Curr Opin Microbiol. 2006 Dec;9(6):547-52. doi: 10.1016/j.mib.2006.09.002. Epub 2006 Oct 11.


Multinucleated cells are found in diverse contexts and include filamentous fungi, developing insect embryos, skeletal muscle and metastasizing tumor cells. Some multinucleated cells such as those in muscles arise from cell fusion events, but many are formed through specialized cell cycles in which nuclear and cell division are uncoupled. Recent work in the fungus Ashbya gossypii illustrates how unique spatial and temporal regulation of conserved cell cycle regulators directs mitosis in multinucleated cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism*
  • Cell Nucleus / metabolism*
  • Cell Nucleus / physiology
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism
  • Fungi / genetics
  • Fungi / physiology*
  • Hyphae / growth & development*
  • Mitosis*


  • Cell Cycle Proteins
  • Fungal Proteins