CO2 Sensing in Fungi and Beyond

Curr Opin Microbiol. 2006 Dec;9(6):572-8. doi: 10.1016/j.mib.2006.09.003. Epub 2006 Oct 11.


Carbon dioxide is not only an important gaseous molecule for maintenance of the biosphere homeostasis, but is also a crucial signalling cue in living cells. Fungal pathogens, including Candida albicans and Cryptococcus neoformans, must adapt to dramatic changes in CO2 levels during colonization and subsequent infection of their human host. Recent reports provide insight into how pathogenic fungi sense environmental CO2 and the role of carbonic anhydrase and fungal adenylyl cyclase in CO2 sensing.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenylyl Cyclases / metabolism*
  • Animals
  • Carbon Dioxide / metabolism*
  • Carbonic Anhydrases / metabolism
  • Fungi / enzymology*
  • Fungi / metabolism
  • Gene Expression Regulation, Fungal*
  • Phylogeny
  • Signal Transduction / physiology*


  • Carbon Dioxide
  • Carbonic Anhydrases
  • Adenylyl Cyclases