Abstract
Mitotic chromosome structure has been the cell biology equivalent of a 'riddle, wrapped in a mystery, inside an enigma'. Observations that genetic knockout or knockdown of condensin subunits or topoisomerase II cause only minimal perturbation in overall chromosome condensation, together with analysis of early stages of chromosome condensation and effects produced by histone H1 depletion, suggest a need to reconsider textbook models of mitotic chromosome condensation and organization.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Adenosine Triphosphatases / genetics
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Adenosine Triphosphatases / metabolism
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Adenosine Triphosphatases / ultrastructure*
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Animals
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Chromatin / genetics
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Chromatin / metabolism
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Chromatin / ultrastructure
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Chromosome Segregation / genetics*
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Chromosomes / genetics
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Chromosomes / metabolism
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Chromosomes / ultrastructure*
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DNA Topoisomerases, Type II / genetics
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DNA Topoisomerases, Type II / metabolism
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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DNA-Binding Proteins / ultrastructure*
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Histones / genetics
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Histones / metabolism
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Humans
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Mitosis / genetics*
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Models, Biological
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Multiprotein Complexes / genetics
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Multiprotein Complexes / metabolism
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Multiprotein Complexes / ultrastructure*
Substances
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Chromatin
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DNA-Binding Proteins
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Histones
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Multiprotein Complexes
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condensin complexes
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Adenosine Triphosphatases
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DNA Topoisomerases, Type II