Long-term monitoring of gait in Parkinson's disease

Gait Posture. 2007 Jul;26(2):200-7. doi: 10.1016/j.gaitpost.2006.09.011. Epub 2006 Oct 13.


A new system for long-term monitoring of gait in Parkinson's disease (PD) has been developed and validated. The characteristics of every stride taken over 10-h epochs were acquired using a lightweight ankle-mounted sensor array that transmitted data wirelessly to a small pocket PC at a rate of 100 Hz. Stride was calculated from the vertical linear acceleration and pitch angular velocity of the leg with an accuracy of 5 cm. Results from PD patients (5) demonstrate the effectiveness of long-term monitoring of gait in a natural environment. The small, variable stride length characteristic of Parkinsonian gait, and fluctuations of efficacy associated with levodopa therapy, such as delayed onset, wearing off, and the 'off/on' effect, could reliably be detected from long-term changes in stride length.

Publication types

  • Evaluation Study
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Algorithms
  • Antiparkinson Agents / administration & dosage
  • Antiparkinson Agents / adverse effects
  • Antiparkinson Agents / pharmacology*
  • Calibration
  • Computers, Handheld
  • Drug Monitoring / instrumentation*
  • Dyskinesia, Drug-Induced / physiopathology
  • Dyskinesia, Drug-Induced / prevention & control
  • Electronics, Medical
  • Feasibility Studies
  • Female
  • Gait
  • Gait Disorders, Neurologic / etiology
  • Gait Disorders, Neurologic / physiopathology
  • Humans
  • Levodopa / administration & dosage
  • Levodopa / adverse effects
  • Levodopa / pharmacology*
  • Male
  • Middle Aged
  • Monitoring, Ambulatory / instrumentation*
  • Parkinson Disease / complications
  • Parkinson Disease / drug therapy*


  • Antiparkinson Agents
  • Levodopa