Exiting the outside world for cross-presentation

Immunity. 2006 Oct;25(4):523-5. doi: 10.1016/j.immuni.2006.09.003.


How are extracellular proteins cross-presented on MHC class I molecules? In this issue of Immunity, demonstrate that the ER-associated degradation (ERAD) export pathway operates in the phagosomes of dendritic cells and transfers antigens into the MHC class I pathway.

Publication types

  • Comment

MeSH terms

  • Antigen Presentation*
  • Cross-Priming*
  • Dendritic Cells / immunology*
  • Dendritic Cells / ultrastructure
  • Endoplasmic Reticulum / metabolism
  • Histocompatibility Antigens Class I / metabolism*
  • Humans
  • Phagosomes / metabolism*
  • Protein Transport
  • Proteins / metabolism


  • Histocompatibility Antigens Class I
  • Proteins