Fraser syndrome in a 96-year-old female

Age Ageing. 2006 Nov;35(6):642-3. doi: 10.1093/ageing/afl109.


Fraser syndrome is an autosomal recessive disorder in which the life expectancy is <1 year. The main features are cryptophthalmos, ear, nose and skeletal malformations, syndactyly, laryngeal stenosis and malformation of the uro-genital system, lungs, liver and central nervous system (CNS). We report the clinical, laboratory and post-mortem findings of this condition in an elderly woman aged 96 years. She is the oldest known patient with Fraser syndrome.

Publication types

  • Case Reports

MeSH terms

  • Age Factors
  • Aged, 80 and over
  • Eyelids / abnormalities*
  • Face / pathology
  • Female
  • Humans
  • Syndactyly / pathology*
  • Syndrome