Fluorine concentrations in bone biopsy samples determined by proton-induced gamma-ray emission and cyclic neutron activation

Biol Trace Elem Res. 1990 Jul-Dec:26-27:161-8. doi: 10.1007/BF02992669.


Fluorine concentrations in bone biopsy samples taken from the iliac crest of subjects, divided into four groups depending on the length of dialysis treatment, and aluminium levels in blood and bone pathology, in terms of osteoporosis, were determined by two instrumental methods. Proton-induced gamma-ray emission (PIGE), making use of the resonance reaction of 19F(p, alpha gamma)16O at 872 keV, and cyclic neutron activation analysis (CNAA), using the 19F(n, gamma)20F reaction in a reactor irradiation facility, were employed. Rutherford backscattering (RBS) was used to calculate the volume, and, hence, mass of the sample excited in PIGE by determining the major element composition of the samples in order to express results in terms of concentration. From this preliminary investigation, a relationship is suggested between fluorine concentrations in bone and aluminium levels in the system.

Publication types

  • Comparative Study

MeSH terms

  • Aluminum / blood
  • Bone and Bones / chemistry*
  • Evaluation Studies as Topic
  • Fluorine / analysis*
  • Humans
  • Neutron Activation Analysis / methods*
  • Osteoporosis / etiology
  • Osteoporosis / metabolism
  • Renal Dialysis / adverse effects
  • Spectrometry, Gamma / methods*


  • Fluorine
  • Aluminum