Tau phosphorylation, aggregation, and cell toxicity

J Biomed Biotechnol. 2006;2006(3):74539. doi: 10.1155/JBB/2006/74539.


Protein aggregation takes place in many neurodegenerative disorders. However, there is a controversy about the possible toxicity of these protein aggregates. In this review, this controversy is discussed, focussing on the tau aggregation that takes place in those disorders known as tauopathies.