Genetics of global gene expression

Nat Rev Genet. 2006 Nov;7(11):862-72. doi: 10.1038/nrg1964.


A new field of genetic analysis of global gene expression has emerged in recent years, driven by the realization that traditional techniques of linkage and association analysis can be applied to thousands of transcript levels measured by microarrays. Genetic dissection of transcript abundance has shed light on the architecture of quantitative traits, provided a new approach for connecting DNA sequence variation with phenotypic variation, and improved our understanding of transcriptional regulation and regulatory variation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Fungal Proteins / genetics
  • Gene Expression*
  • Genetic Techniques
  • Genetic Variation
  • Humans
  • Molecular Sequence Data
  • Quantitative Trait Loci
  • Sequence Homology, Amino Acid
  • Transcription, Genetic
  • Yeasts / genetics


  • Fungal Proteins