Efficient and Direct Synthesis of Poly-Substituted indeno[1,2-b]quinolines Assisted by P-Toluene Sulfonic Acid Using High-Temperature Water and Microwave Heating via One-Pot, Three-Component Reaction

Org Biomol Chem. 2006 Nov 7;4(21):3980-5. doi: 10.1039/b611462h. Epub 2006 Sep 29.


Reactions of aldehydes, 1,3-indanedione and enaminones were successfully carried out using p-toluene sulfonic acid (p-TsOH) as a catalyst and high-temperature water as a solvent under microwave irradiation. This method provided several advantages such as rapid reaction times, high yields, and a simple workup procedure. In addition, a possible mechanism to account for the reaction was proposed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Hot Temperature*
  • Microwaves*
  • Quinolines / chemical synthesis*
  • Quinolines / chemistry
  • Sulfonic Acids / chemistry*
  • Toluene / chemistry*
  • Water / chemistry*


  • Quinolines
  • Sulfonic Acids
  • Water
  • Toluene