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Review
, 41 (9), 832-6

The Role of Trypsin, Trypsin Inhibitor, and Trypsin Receptor in the Onset and Aggravation of Pancreatitis

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Review

The Role of Trypsin, Trypsin Inhibitor, and Trypsin Receptor in the Onset and Aggravation of Pancreatitis

Masahiko Hirota et al. J Gastroenterol.

Abstract

Trypsin activity is properly suppressed in the pancreatic acinar cells under normal conditions. A small amount of trypsinogen is converted to active trypsin and inactivated by pancreatic secretory trypsin inhibitor (PSTI), thereby preventing damage to pancreatic acinar cells as a first line of defense. However, if trypsin activation (due to excessive stimulation of pancreatic acinar cells) exceeds the capacity of PSTI, a subsequent cascade of events leads to the activation of various proteases that damage cells. This can be interpreted as the main causative event of pancreatitis onset. Trypsin produced in and secreted from the pancreatic acinar cells activates protease activated receptor-2 (PAR-2), which is present at high densities on the luminal surfaces of pancreatic acinar cells and duct cells. Results of PAR-2 activation are the production of cytokines and the regulation of exocrine function via a negative feedback loop. Thus, the actions of trypsin, trypsin inhibitor (PSTI), and trypsin receptor (PAR-2) in the pancreas are strongly interconnected.

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References

    1. J Gastroenterol. 2001 Sep;36(9):612-8 - PubMed
    1. Gut. 1991 Aug;32(8):945-8 - PubMed
    1. Am J Physiol Gastrointest Liver Physiol. 2005 Feb;288(2):G388-95 - PubMed
    1. JOP. 2003 Mar;4(2):83-8 - PubMed
    1. Nat Genet. 2000 Jun;25(2):213-6 - PubMed

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