Leukocyte removal therapy for ulcerative colitis does not affect postoperative complications

J Gastroenterol. 2006 Sep;41(9):848-54. doi: 10.1007/s00535-006-1875-1.


Background: We investigated the incidence of postoperative complications in patients treated with or without preoperative leukocyte removal therapy (LRT).

Methods: The case notes of 387 patients with ulcerative colitis (UC) who underwent surgical intervention were retrospectively reviewed. One hundred nine patients were treated with LRT within 8 weeks before surgery (LRT group), and 278 had not received LRT since at least 8 weeks before surgery (without LRT group). We reviewed the postoperative complications according to type of initial operation.

Results: Of the patients who underwent an ileal J-pouch anal anastomosis (IPAA) without an ileostomy, 3 (6.5%) in the LRT group developed pouch-related complications (PRC), while 11 (7.5%) in the without LRT group developed PRC. The overall postoperative complication rates were 28.3% in the LRT group and 21.8% in the without LRT group. For patients who underwent an IPAA with an ileostomy, the overall rates of postoperative complications were 39.1% in the LRT group and 31.8% in the without LRT group. Among those undergoing a total colectomy, 33.3% in the LRT group and 18.2% in the without LRT group had postoperative complications. No statistically significant differences were demonstrated between the two groups with respect to postoperative complications.

Conclusions: Our results suggest that preoperative LRT does not influence the rate of postoperative complications in UC patients.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Colitis, Ulcerative / surgery*
  • Colonic Pouches / adverse effects
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Leukocyte Reduction Procedures / methods*
  • Male
  • Middle Aged
  • Postoperative Complications / epidemiology
  • Postoperative Complications / prevention & control*
  • Proctocolectomy, Restorative / adverse effects*
  • Retrospective Studies
  • Treatment Outcome