Human acellular dermal matrix for closure of a contaminated gynecologic wound

Gynecol Oncol. 2006 Oct;103(1):354-6. doi: 10.1016/j.ygyno.2006.04.020.


Background: Polypropylene mesh for abdominal wall reconstruction increases the risk of postoperative complications in previously irradiated patients or patients with contaminated operative fields. A novel alternative, acellular dermal matrix, easily incorporates into native tissue when used for fascial reconstruction, forming a strong repair with minimal adhesions and lower infection rates.

Case: We describe a patient previously treated with radiation for cervical cancer who presented with a contaminated operative field due to enteral spillage and pelvic infection. Acellular dermal matrix was used as part of a stepwise secondary closure of a large fascial defect in the anterior abdominal wall that was the result of repeated surgical procedures.

Conclusion: Use of acellular dermal matrix rather than traditional polypropylene mesh should be considered for patients with contaminated or irradiated operative fields.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Gynecologic Surgical Procedures / adverse effects
  • Gynecologic Surgical Procedures / methods*
  • Humans
  • Postoperative Complications / prevention & control
  • Skin, Artificial*
  • Surgical Wound Infection / therapy*
  • Uterine Cervical Neoplasms / drug therapy
  • Uterine Cervical Neoplasms / radiotherapy
  • Uterine Cervical Neoplasms / surgery*