pH- and temperature-sensitive, injectable, biodegradable block copolymer hydrogels as carriers for paclitaxel

Int J Pharm. 2007 Feb 22;331(1):11-8. doi: 10.1016/j.ijpharm.2006.09.027. Epub 2006 Sep 23.


Paclitaxel (PTX) was loaded into synthetic pH/T-sensitive block copolymer (OSM-PCLA-PEG-PCLA-OSM) solution with various concentrations. The phase diagram of PTX-loaded block copolymer solution shifted to lower temperature region compared to net block copolymer because of the salting-out effect of PTX. Release profiles of PTX showed sustained manner regardless of loading amount of PTX. To evaluate anti-tumor effect of PTX-loaded block copolymer, solutions were injected subcutaneously to tumor-bearing mice and TUNEL assay examined. PTX-loaded block copolymer hydrogel for in vivo use showed good anti-tumor effect for 2 weeks and induced strong apoptosis in tumor tissue. Therefore, we conclude OSM-PCLA-PEG-PCLA-OSM block copolymer as an effective injectable carrier of PTX.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Apoptosis
  • Delayed-Action Preparations
  • Drug Carriers / chemistry*
  • Hydrogels / chemistry*
  • Hydrogen-Ion Concentration
  • In Situ Nick-End Labeling
  • Injections, Subcutaneous
  • Male
  • Melanoma, Experimental / drug therapy
  • Melanoma, Experimental / pathology
  • Mice
  • Mice, Inbred C57BL
  • Paclitaxel / chemistry*
  • Paclitaxel / pharmacology
  • Polymers / chemistry*
  • Skin Neoplasms / drug therapy
  • Skin Neoplasms / pathology
  • Temperature


  • Antineoplastic Agents, Phytogenic
  • Delayed-Action Preparations
  • Drug Carriers
  • Hydrogels
  • Polymers
  • Paclitaxel