Preventing depression in adolescents with epilepsy

Epilepsy Behav. 2006 Dec;9(4):619-24. doi: 10.1016/j.yebeh.2006.08.017. Epub 2006 Oct 17.


Purpose: The goal of the work described in this article was to test the possibility of preventing depression among adolescents with epilepsy.

Methods: Adolescents with newly diagnosed epilepsy (104 patients) were screened for depression. The risk for depression was increased in 30 (28.8%) patients (mean age 17.4, 60% females) who were randomized into two equal treatment groups: (1) cognitive-behavioral intervention (CBI) group and (2) treatment with counseling as usual (TAU) group. The Beck Depression Inventory (BDI), Center for Epidemiological Study on Depression (CES-D) scale, Hamilton Depression Scale (HAMD), and Quality of Life in Epilepsy Inventory (QOLIE-31) were administered at baseline and during the 9-month follow-up.

Results: Initial BDI and HAMD scores for the two groups were comparable. Depression was diagnosed during follow-up in three patients in the TAU group. Subthreshold depressive disorder significantly improved at follow-up in the BCI group compared with the TAU group (P<0.05). QOLIE-31 Total scores significantly correlated with both mood improvement and seizure-free state.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adaptation, Psychological
  • Adolescent
  • Adult
  • Cognitive Behavioral Therapy*
  • Counseling*
  • Depression / diagnosis
  • Depression / etiology
  • Depression / prevention & control*
  • Epilepsy / complications
  • Epilepsy / psychology*
  • Female
  • Humans
  • Male
  • Risk Factors