Presence of the exoU gene of Pseudomonas aeruginosa is correlated with cytotoxicity in MDCK cells but not with colonization in BALB/c mice

Hsi-Hsun Lin; Shiao-ping Huang; Hsiu-Chen Teng; Dar-Der Ji; Yao-Shen Chen; Ya-Lei Chen

doi:10.1128/JCM.01531-06

Presence of the exoU gene of Pseudomonas aeruginosa is correlated with cytotoxicity in MDCK cells but not with colonization in BALB/c mice

J Clin Microbiol. 2006 Dec;44(12):4596-7. doi: 10.1128/JCM.01531-06. Epub 2006 Oct 18.

Authors

Hsi-Hsun Lin¹, Shiao-ping Huang, Hsiu-Chen Teng, Dar-Der Ji, Yao-Shen Chen, Ya-Lei Chen

Affiliation

¹ Department of Infectious Disease, E-DA Hospital/I-Shou University, Kaoshiung, Taiwan.

Abstract

A total of 141 independent strains of Pseudomonas aeruginosa with different heterogeneities in the exo gene (exoS, exoT, exoU, and exoY) background were examined for their pathogenic roles. Results indicated that the exoU gene is the major contributor to cytotoxicity in Madin-Darby canine kidney cells but is not related to bacterial colonization in mice.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bacterial Proteins / genetics*
Cell Death*
Cell Line
Disease Models, Animal
Dogs
Genes, Bacterial
Mice
Mice, Inbred BALB C
Pseudomonas Infections / microbiology
Pseudomonas aeruginosa / genetics
Pseudomonas aeruginosa / pathogenicity*
Virulence / genetics
Virulence Factors / genetics*

Substances

Bacterial Proteins
Virulence Factors
pseudomonas exoprotein A protein, Pseudomonas aeruginosa