OBJECTIVE.: To compare the treatment outcome of cervical intraepithelial neoplasia (CIN 2,3) on HIV-infected and uninfected women treated by cryotherapy or loop electrosurgical excision procedure (LEEP). METHODS.: A total of 147 women were recruited into the study between April 1997 and May 1998. Cryotherapy was performed in 75 women and LEEP in 72 women after randomization. RESULTS.: A total of 109 (74.1%) women tested positive and 38 (25.9%) tested negative for HIV-1. At 12 months follow-up visit, cryotherapy had 59.5% cure rate on HIV-positive women and 84.2% success among HIV-negative women (p = .057). LEEP had 86% cure rate on HIV-positive and 100% cure rate on HIV-negative women (p = .328). CONCLUSION.: HIV-1-infected women harboring cervical squamous intraepithelial lesions have a high failure rate (40.5%) when treated by cryotherapy.