A network dysfunction perspective on neurodegenerative diseases

Nature. 2006 Oct 19;443(7113):768-73. doi: 10.1038/nature05289.


Patients with Alzheimer's disease or other neurodegenerative disorders show remarkable fluctuations in neurological functions, even during the same day. These fluctuations cannot be caused by sudden loss or gain of nerve cells. Instead, it is likely that they reflect variations in the activity of neural networks and, perhaps, chronic intoxication by abnormal proteins that the brain is temporarily able to overcome. These ideas have far-reaching therapeutic implications.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Alzheimer Disease / drug therapy
  • Alzheimer Disease / pathology
  • Alzheimer Disease / physiopathology
  • Animals
  • Humans
  • Neurodegenerative Diseases / drug therapy
  • Neurodegenerative Diseases / pathology
  • Neurodegenerative Diseases / physiopathology*
  • Neuronal Plasticity
  • Synapses / metabolism