Cell death in the nervous system

Nature. 2006 Oct 19;443(7113):796-802. doi: 10.1038/nature05293.


Neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease trigger neuronal cell death through endogenous suicide pathways. Surprisingly, although the cell death itself may occur relatively late in the course of the degenerative process, the mediators of the underlying cell-death pathways have shown promise as potential therapeutic targets.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis* / drug effects
  • Autophagy
  • Cell Death / drug effects
  • Endoplasmic Reticulum / metabolism
  • Humans
  • Nervous System / pathology*
  • Neurodegenerative Diseases / drug therapy
  • Neurodegenerative Diseases / metabolism
  • Neurodegenerative Diseases / pathology*