Abstract
A fructo-oligosaccharide was isolated from Chlorophytum borivilianum and identified as O-beta-D-fructofuranosyl-(2-->1)-(beta-D-fructofuranosyl) (n)-(2-->1)-alpha-D-glucopyranoside (n = 5 - 30) using high-pressure anion exchange chromatography, MALDI-MS, NMR, GC, HPTLC and chemical analysis. The extract and the fructo-oligosaccharide were found to have significant antidiabetic activity with the blood sugar levels being 118.32 +/- 3.56 and 110.21 +/- 4.22, respectively, as compared to the control value of 231.25 +/- 3.03 along with moderate antioxidant activity in streptozotocin-induced diabetic animals.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Asparagaceae / chemistry*
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Blood Glucose / drug effects
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Diabetes Mellitus, Experimental / chemically induced
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Diabetes Mellitus, Experimental / drug therapy*
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Disease Models, Animal
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Hypoglycemic Agents / administration & dosage
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Hypoglycemic Agents / pharmacology*
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Hypoglycemic Agents / therapeutic use
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Male
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Oligosaccharides / administration & dosage
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Oligosaccharides / pharmacology
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Oligosaccharides / therapeutic use
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Oxidative Stress / drug effects*
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use
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Plants, Medicinal
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Rats
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Rats, Sprague-Dawley
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Streptozocin
Substances
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Blood Glucose
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Hypoglycemic Agents
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Oligosaccharides
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Plant Extracts
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Streptozocin