Evidence that Fluoro-Gold can be transported avidly through fibers of passage

Brain Res. 1990 Nov 19;533(2):329-33. doi: 10.1016/0006-8993(90)91358-n.

Abstract

Small iontophoretic injections of the retrograde tracer Fluoro-Gold were restricted to the dorsal columns in the cervical enlargement of 6 rats. Large numbers of neurons were labeled in the lumbosacral dorsal horn in each rat. In the most effective case, more than 1800 neurons were labeled in alternate sections through nine examined segments. Many neurons were also labeled in lumbosacral dorsal root ganglia of all cases. This study, in contrast to previous reports, indicates that Fluoro-Gold can be transported avidly by axons passing through, but not terminating in, injection sites.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Axonal Transport*
  • Biological Transport / physiology
  • Fluorescent Dyes*
  • Injections
  • Iontophoresis
  • Male
  • Necrosis
  • Neurons / metabolism
  • Neurons / pathology
  • Rats
  • Rats, Inbred Strains
  • Spinal Cord / cytology
  • Spinal Cord / metabolism*
  • Spinal Cord / pathology
  • Stilbamidines*

Substances

  • 2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt
  • Fluorescent Dyes
  • Stilbamidines