Efficacy of mangiferin on serum and heart tissue lipids in rats subjected to isoproterenol induced cardiotoxicity

Toxicology. 2006 Dec 7;228(2-3):135-9. doi: 10.1016/j.tox.2006.08.030. Epub 2006 Sep 1.

Abstract

The efficacy of mangiferin, on metabolism of lipids was tested in experimental cardiotoxic rats. The cardiotoxicity was induced by myocardial infarction through subcutaneous administration of isoproterenol hydrochloride for 2 days using 0.1 ml saline. Mangiferin drug was given as pretreatment for 28 days through intraperitonial administration using 0.2 ml dimethyl sulphoxide. Mangiferin significantly reduced the cholesterol, triglycerol, free fatty acids levels in serum and heart of the cardiotoxic myocardial infarcted rats. Mangiferin also increased the level of heart tissue phospholipids significantly in isoproterenol induced cardio toxic rats. The experiment thus concludes that mangiferin possess cardioprotective and hypolipidemic effect on experimentally induced cardiotoxic myocardial infarcted rats.

MeSH terms

  • Adrenergic beta-Agonists / toxicity*
  • Animals
  • Cardiotonic Agents*
  • Cholesterol / blood
  • Cholesterol / metabolism
  • Fatty Acids, Nonesterified / blood
  • Fatty Acids, Nonesterified / metabolism
  • Heart / drug effects*
  • Heart Diseases / chemically induced*
  • Heart Diseases / metabolism*
  • Hypolipidemic Agents*
  • Isoproterenol / toxicity*
  • Lipid Metabolism / drug effects*
  • Lipids / blood*
  • Male
  • Myocardial Infarction / chemically induced
  • Myocardial Infarction / metabolism
  • Myocardial Infarction / prevention & control
  • Myocardium / metabolism*
  • Phospholipids / metabolism
  • Rats
  • Rats, Wistar
  • Triglycerides / blood
  • Triglycerides / metabolism
  • Xanthones / chemistry
  • Xanthones / pharmacology*

Substances

  • Adrenergic beta-Agonists
  • Cardiotonic Agents
  • Fatty Acids, Nonesterified
  • Hypolipidemic Agents
  • Lipids
  • Phospholipids
  • Triglycerides
  • Xanthones
  • mangiferin
  • Cholesterol
  • Isoproterenol