Assessing health-related quality of life in patients with Parkinson's disease in a prospective longitudinal study

Parkinsonism Relat Disord. 2007 Mar;13(2):108-14. doi: 10.1016/j.parkreldis.2006.07.009. Epub 2006 Oct 19.


Objective: To prospectively assess the health-related quality of life (HrQoL) in Parkinson's disease (PD) during 12 months.

Methods: HrQoL was assessed in 145 PD patients using the PD-specific PDQ-39, PDQL and the generic EQ-5D. In addition, clinical rating-scales were used.

Results: All scales showed a pronounced effect of PD. In comparison to an age-matched population the EQ-5D was considerably affected. In comparison to baseline, however, there was no significant change in the generic scale but a significant change in the sum-score of disease-specific HrQoL-scales.

Conclusions: Only disease-specific scales were sensitive to change. Further studies are necessary to evaluate the time-dependent change in HrQoL.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Female
  • Health Status*
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Parkinson Disease / physiopathology*
  • Parkinson Disease / psychology*
  • Psychometrics
  • Quality of Life*
  • Severity of Illness Index
  • Sickness Impact Profile