Bioorthogonal noncovalent chemistry: Fluorous phases in chemical biology

Curr Opin Chem Biol. 2006 Dec;10(6):576-83. doi: 10.1016/j.cbpa.2006.10.007. Epub 2006 Oct 19.


Chemical entities designed to noncovalently interact with predetermined partners have fashioned a new paradigm in chemical biology. Fluorocarbons are extremely promising as supramolecular synthons toward these objectives. Bioorthogonal noncovalent interactions provide a way to modulate self-assembled systems in environments where such control has hitherto not been possible. Fluorocarbons have now found applications in self-assembly as well as proteomics, biomolecule purification and in the creation of microarray platforms. Other self-assembly motifs with similar attributes might be exploited using the same general approach.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Cell Adhesion
  • Fluorocarbons / chemistry*
  • Proteomics


  • Fluorocarbons