Metabotropic glutamate receptors: intracellular signaling pathways

Curr Opin Pharmacol. 2007 Feb;7(1):56-61. doi: 10.1016/j.coph.2006.08.008. Epub 2006 Oct 19.


Metabotropic glutamate receptors are classified into three groups, primarily on the basis of sequence similarity and whether they positively couple to the phospholipase C cascade or negatively couple to adenylyl cyclases. The past decade of research, drawing on sophisticated molecular approaches, has revealed a multitude of additional intracellular components that assemble as protein scaffolds around neuronal metabotropic glutamate receptors, establishing functional links to postsynaptic density structures, to membrane-bound enzymes and ion channels, and to the nucleus. Characterization of these novel transduction mechanisms is providing new insights into the roles of metabotropic glutamate receptors in the regulation and modulation of diverse functions in the nervous system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Arrestins / metabolism
  • Calcium / metabolism
  • GTP-Binding Proteins / metabolism
  • Neurons / metabolism
  • Protein Biosynthesis
  • Receptors, Metabotropic Glutamate / metabolism*
  • Signal Transduction
  • Transcription, Genetic
  • beta-Arrestins


  • Arrestins
  • Receptors, Metabotropic Glutamate
  • beta-Arrestins
  • GTP-Binding Proteins
  • Calcium